2.

Points allocated to each prognostic factor to calculate an overall prognostic score for OS and PFS.

	0	1	2	3	4	5
<LLN, below the lower limit of normal; >ULN, above the upper limit of normal; ECOG PS, Eastern Cooperative Oncology Group performance status; LDH, lactic dehydrogenase; LMR, lymphocyte to monocyte ratio; WBC, white blood cells
EGFR mutation	DEL19/L858R/ Other					T790M
Gender	Female	Male
Smoking history	Never		Current or previous
Time from diagnosis	> 12 months				< 12 months
ECOG PS	0	1+
Liver metastases	No			Yes
Brain metastases	No			Yes
Bone metastases	No			Yes
Pleural effusion metastases	No			Yes
LDH	Normal		> ULN
Haemoglobin	Normal	< LLN
WBC	Normal					> ULN
LMR below 3	No	Yes