2.

Univariate and multivariate analysis of predictive factors of upstaging

Characteristics	Cases of DCIS (n = 290)	%	Cases of DCISM & IBC (n = 314)	%	Univariate P-value	Multivariate OR (95% CI), P
DCIS, ductal carcinoma in situ; DCISM, ductal carcinoma in situ with microinvasion; IBC, invasive breast cancer; OR, odd ratio; CI, confidence interval; BC, breast cancer.
Age (years)					0.230
≤ 50	141	48.62	168	53.50
> 50	149	51.38	146	46.50
BC family history					0.229
No	225	77.59	256	81.53
Yes	65	22.41	58	18.47
BMI					0.881
< 25	221	76.21	236	75.16
≥ 25	60	20.69	66	21.02
Unknown	9	3.10	12	3.82
Discharge					0.210
No	255	87.93	265	84.39
Yes	35	12.07	49	15.61
Tumor size on ultrasonography					0.005
≤ 2 cm	127	43.79	102	32.48		Ref
> 2 cm	139	47.93	192	61.15		1.558 (1.094-2.218), 0.014
Unknown	24	8.28	20	6.37
Calcification on mammography					0.169
Yes	163	56.21	200	63.69
No	41	14.14	38	12.10
Unknown	86	29.66	76	24.20
BI-RADS					0.009
3	2	0.69	4	1.27		1.207 (0.211-6.912), 0.833
4A	13	4.48	14	4.46		0.568 (0.233-1.384), 0.213
4B	66	22.76	49	15.61		0.435 (0.259-0.733), 0.002
4C	142	48.97	133	42.36		0.502 (0.329-0.764), 0.001
5	59	20.34	104	33.12		Ref
Unknown	8	2.76	10	3.18