1.
Statistically significant variants from meta-analysis, false-positive report probabilities (FPRP), and cumulative epidemiological evidence
| Gene
(variant) |
Cancer
type (year)Ref |
Comparison | Ethnicity | OR
(95% CI) |
Publication bias/
heterogeneity |
I2(%) | No.
of studies |
Sample
size (cases/ control) |
Number of
test allele or genotype (calculated value according to MAF) |
Maf | Venice criteriaa | Venice
grade |
Power
OR of 1.5 |
FPRP values
at prior probability of 0.001 at power OR of 1.5 |
Cumulative epidemiological
evidenceb |
| ALDH2
(rs671） |
GC
(2017)20 |
AvsG | Asian | 1.17
(1.01–1.36) |
No/0.325 | 0 | 2 | 2982
(1153/1829) |
1618 | 0.2674 | AAA | Strong | 0.999 | 0.976 | Moderate |
| APE1
(rs1760944) |
GC
(2017)21 |
GvsT | Diverse | 1.77
(1.40–2.24) |
>0.05/0.29 | 19 | 4 | 2113
(802/1311) |
1779 | 0.3863 | AAA | Strong | 0.084 | 0.023 | Strong |
| Asian | 1.41
(1.09–1.83) |
Na | Na | Na | Na | Na | Na | ||||||||
| APEX1
(rs1130409) |
GC
(2015)22 |
AspvsGlu | Diverse | 1.42
(1.09–1.84) |
0.16/0.016 | 71 | 4 | 2114
(803/1311) |
Na
(1588) |
0.3756d | XCA | Na | Na | ||
| BIRC5
(rs9904341) |
GC
(2013)23 |
Recessive | Diverse | 1.75
(1.07–2.86) |
0.948/0.053 | 61.2c | 4 | 1147
(583/564) |
293 | 0.4752 | BCA | Weak | 0.269 | 0.990 | Weak |
| CD95
(rs2234767) |
GC
(2013)24 |
Recessive | Diverse | 1.27
(1.05–1.53) |
No/0.495 | 0 | 8 | 4563
(Na/Na) |
Na
(0–840) |
0.1841d | XAA | Na | Na | ||
| Asian | 1.27
(1.05–1.52) |
Na | Na | Na | Na | Na | Na | ||||||||
| COX-2
(rs20417) |
GC
(2013)25 |
Dominant | Diverse | 1.58
(1.06–2.35) |
0.05/0.000 | 85.4 | 10 | 7096
(2198/4898) |
1157 | 0.0779 | ACA | Weak | 0.399 | 0.984 | Weak |
| COX-2
(rs689466) |
GC
(2017)26 |
Dominant | Diverse | 1.24
(1.06–1.45) |
0.690/0.000 | 68.8 | 11 | 7723
(2500/5223) |
6123 | 0.516 | ACA | Weak | 0.991 | 0.876 | Weak |
| DNMT1
(rs16999593) |
GC
(2017)27 |
Dominant | Asian | 1.36
(1.15–1.60) |
0.982/0.720 | 0 | 3 | 2647
(999/1675) |
2558 | 0.8194 | AAA | Strong | 0.881 | 0.191 | Strong |
| DNMT3A
(rs1550117) |
GC
(2016)28 |
Dominant | Asian | 1.20
(1.01–1.42) |
Na/0.04 | 69 | 3 | 2996
(1104/1892) |
Na
(342–684) |
0.1142d | XCX | Na | Na | ||
| EGF
(rs4444903) |
GC
(2015)29 |
GvsA | Diverse | 1.18
(1.00–1.39) |
0.106/0.009 | 66.61 | 7 | 5194
(1992/3202) |
6524 | 0.6071 | ACA | Weak | 0.988 | 0.979 | Weak |
| Asian | 1.23
(1.04–1.46) |
0.106/0.028 | 61.48 | 6 | 4048
(2494/2977) |
5471 | 0.6711 | ACA | Weak | 0.988 | 0.948 | Weak | |||
| Caucasian | 0.91
(0.71–1.15) |
Na | Na | Na | Na | Na | Na | ||||||||
| ERCC2
(rs1052559) |
GC
(2012)30 |
Recessive | Asian | 2.41
(1.69–3.43) |
0.989/0.701 | 0 | 5 | 3246
(1267/1979) |
143 | 0.1266 | BAA | Moderate | 0.002 | 0.055 | Moderate |
| ERCC2
(rs1799793) |
GC
(2012)30 |
Recessive | Diverse | 1.48
(1.12–1.97) |
0.045/0.272 | 19.2 | 9 | 5144
(1715/3429) |
416 | 0.2528 | BAC | Weak | 0.537 | 0.931 | Weak |
| Continued | |||||||||||||||