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. 2019 May;16(2):361–389. doi: 10.20892/j.issn.2095-3941.2018.0290

2.

Statistically significant variants from GWAS

PMID Gene Variant Ethnicity Year OR
(95% CI) 		MAFa Pb Sample
size (cases/
control) 		Power OR of 1.5 FPRP values at prior
probability
of 0.001 at
power OR
of 1.5 		References
Na: Not available.
a Minor allele frequency (MAF) in case/control.
b The P values are all less than 5.00E-08.
26701879 ASH1L rs80142782 Asian 2017 0.62
(0.56–0.69) 		Na 1.71E-19 15191
(5572/9619) 		0.120 0.000 15
26701879 MUC1 rs4072037 Asian 2017 0.74
(0.69–0.79) 		Na 6.28E-17 15191
(5572/9619) 		0.996 0.000 15
26701879 LOC
105379076 		rs7712641 Asian 2017 0.84
(0.80–0.88) 		Na 1.21E-11 15191
(5572/9619) 		1.000 0.000 15
26701879 PSCA rs2294008 Asian 2017 1.20
(1.15–1.28) 		Na 5.95E-11 15191
(5572/9619) 		1.000 0.000 15
26129866 PRKAA1 rs10074991 Asian 2016 0.80
(0.77–0.83) 		Na 4.83E-26 20014
(9758/10256) 		1.000 0.000 14
23103227 LRFN2 rs2494938 Asian 2012 1.18
(1.12–1.25) 		0.26/0.23 4.91E-09 17721
(4332/13399) 		1.000 0.000 13
22037551 ZBTB20 rs9841504 Asian 2011 0.76
(0.69–0.83) 		0.11/0.15 1.70E-09 10176
(4294/5882) 		0.998 0.000 76
22037551 PRKAA1 rs13361707 Asian 2011 1.41
(1.32–1.49) 		0.57/0.48 7.60E-29 10176
(4294/5882) 		0.915 0.000 76
20729852 PLCE1 rs2274223 Asian 2010 1.31
(1.19–1.43) 		0.209/0.259 8.40E-09 5542
(3302/2240) 		0.999 0.000 12
20729852 PLCE1 rs3765524 Asian 2010 1.31
(1.20–1.44) 		0.207–0.259 5.32E-09 5542
(3302/2240) 		0.997 0.000 12
20729852 PLCE1 rs3781264 Asian 2010 1.36
(1.23–1.50)) 		0.152/0.199 3.76E-09 5542
(3302/2240) 		0.975 0.000 12
20729852 PLCE1 rs11187842 Asian 2010 1.34
(1.21–1.49) 		0.147/0.190 2.53E-08 5542
(3302/2240) 		0.981 0.000 12
20729852 PLCE1 rs753724 Asian 2010 1.34
(1.21–1.49) 		0.147/0.190 1.74E-08 5542
(3302/2240) 		0.981 0.000 12