S3.
Inconsistency among meta-analysis
| Gene/
PMID |
Gene
(variant) |
Cancer type | Year | Comparison | Ethnicity | OR
(95% CI) |
Publication bias/
heterogeneity |
I2(%) | No. of studies | Cases/
control |
Number of test allele or genotype
(calculated value according to MAF) |
Maf |
| BIRC5-31G/C | ||||||||||||
| 21611748 | BIRC5
(rs9904341) |
GC | 2012 | CC vs. GG | Diverse | 2.88
(0.55–15.00) |
0.525/Na | Na | 3 | 707
(363/344） |
Na
(0–275) |
0.3886b |
| 23405077 | BIRC5
(rs9904341) |
GC | 2013 | CC vs. GG+GC | Diverse | 1.75
(1.07–2.86) |
0.948/0.053 | Naa | 4 | 1147
(583/564) |
293 | 0.4752 |
| 24077840 | BIRC5
(rs9904341) |
GC | 2014 | CC vs. GG | Diverse | 2.21
(1.06–4.64) |
0.317/0.013 | 72.4 | 4 | 1275
(451/824) |
Na
(0–495) |
0.3886b |
| CDH1 | ||||||||||||
| 21214416 | CDH1
(rs16260) |
GC | 2011 | AA+AC vs. CC | Diverse | 1.03
(0.86–1.22) |
0.114/0.005 | Naa | 15 | 6196
(2509/3687) |
2909 | 0.2719 |
| AA+AC vs. CC | Asian | 0.84
(0.72–0.99) |
0.114/0.185 | Naa | 7 | 2671
(1220/1451) |
1049 | 0.2191 | ||||
| AA+AC vs. CC | European | 1.26
(0.98–1.61) |
0.114/0.022 | Naa | 8 | 3525
(1289/2236) |
1860 | 0.3061 | ||||
| 21570316 | CDH1
(rs16260) |
GC | 2011 | AA vs. AC+CC | Diverse | 1.50
(1.03–2.19) |
0.54/Na | Naa | 17 | 8337
(3511/4826) |
586 | 0.2582 |
| 21612411 | CDH1
(rs16260) |
GC | 2011 | AA vs. AC+CC | Diverse | 1.16
(0.83–1.63) |
0.606/0.004 | Naa | 14 | 6421
(3723/2698) |
488 | 0.2732 |
| 24870781 | CDH1
(rs16260) |
GC | 2014 | AA+AC vs. CC | Diverse | 1.11
(0.95–1.30) |
No/0.026 | 48.3 | 13 | 6412
(2722/3690) |
Na
(1510–3021) |
0.2356b |
| 25599647 | CDH1
(rs16260) |
GC | 2015 | AA vs. CC | Diverse | 1.19
(0.89–1.58) |
0.323/0.001 | 55 | 22 | 9679
(4218/9679) |
672 | 0.2545 |
| CDH1 | ||||||||||||
| 21570316 | CDH1
(+54 T>C) |
GC | 2011 | CC vs. CT+TT | Diverse | 1.00
(0.75–1.34） |
Na/Na | Naa | 5 | 2280
(996/1284) |
248 | 0.2667 |
| 24870781 | CDH1 +54 T>C | GC | 2014 | CC+CT vs. TT | Diverse | 0.57
(0.44–0.75) |
No/0.097 | 57.1 | 3 | 1373
(643/730) |
Na
(434–868) |
0.1546b |
| DNMT3B | ||||||||||||
| 27356727 | DNMT3B
(rs1569686) |
GC | 2016 | G vs. T | Diverse | 0.75
(0.30–1.88) |
>0.05/0.00 | 91 | 2 | 1928
(706/1222) |
356 | 0.0953 |
| 27789275 | DNMT3B
(rs1569686) |
GC | 2016 | Dominant | Asian | 0.74
(0.61–0.90) |
Na/0.000 | 81 | 5 | 3014
(1225/1789) |
Na
(832–1664) |
0.2762b |
| 29332452 | DNMT3B
(rs1569686) |
GC | 2017 | T vs. G | Asian | 1.69
(1.36–2.10) |
Na/0.48 | 0 | 3 | 1891
(769/1122) |
3342 | 0.8614 |
| EGF | ||||||||||||
| 20033794 | EGF G61A
(rs4444903) |
GC | 2010 | A vs. G | Asian | 0.80
(0.71–0.92) |
0.033/0.389 | Naa | 3 | 2359
(1019/1340) |
1370 | 0.3104 |
| 20207214 | EGF 61A>G
(rs4444903) |
GC | 2010 | Dominant | Asian | 1.40
(1.03–1.90) |
0.108/0.86 | 0 | 3 | 2359
(1019/1340) |
2159 | 0.6896 |
| 23403233 | EGF 61A>G
(rs4444903) |
GC | 2013 | G vs. A | Diverse | 1.16
(0.96–1.39) |
0.476/0.065 | 58.5 | 4 | 3505
(1181/3505) |
4401 | 0.5936 |
| 25729328 | EGF 61A>G
(rs4444903) |
GC | 2014 | Dominant | Diverse | 1.256
(1.025–1.539) |
0.738/0.468 | 0 | 6 | 4309
(1547/2762) |
Na
(1701–3402) |
0.3948b |
| Dominant | Asian | 1.473
(1.134–1.914) |
0.738/0.928 | 0 | 5 | 3115
(1340/1775) |
Na
(1230–2460) |
0.3948b | ||||
| Continued | ||||||||||||