2.

Association between cancer phenotype and PSP94 expression alone and in combination with PTEN status

Parameter	Evaluable (n)	PSP94				P	Evaluable (n)	PTEN normal			PTEN deletion		P
		Negative	Weak	Moderate	Strong			Negative	Positive*		Negative	Positive*
PTEN, phosphatase and tensin homolog; *positive denotes weak, moderate and strong PSP94 staining.
All cancers	9,881	42.0	33.4	15.2	9.4		5,700	35.9	45.8		7.5	10.8
Tumor stage						< 0.0001							< 0.0001
pT2	6,438	39.9	34.6	15.6	10.0		3587	36.8	51.7		4.2	7.2
pT3a	2,179	43.2	32.5	15.0	9.3		1310	34.7	38.9		10.6	15.7
pT3b-pT4	1,224	51.5	28.9	13.0	6.6		784	33.9	29.6		17.3	19.1
Gleason grade						< 0.0001							< 0.0001
≤3+3	2,296	40.3	31.0	17.5	11.2		1140	38.0	53.3		3.7	5.0
3+4	5,078	39.4	35.5	15.7	9.5		3109	34.9	48.7		5.8	10.6
3+4 Tertiary 5	346	42.2	37.9	10.7	9.3		224	35.3	46.0		6.7	12.1
4+3	840	46.3	32.0	14.4	7.3		577	35.5	32.8		14.0	17.7
4+3 Tertiary 5	485	47.8	34.0	11.8	6.4		338	33.1	33.7		14.8	18.3
≥4+4	383	59.5	26.1	7.3	7.1		307	43.0	26.1		18.6	12.4
Quantitative Gleason						< 0.0001							< 0.0001
≤3+3	2,296	40.3	31.0	17.5	11.2		1140	38.0	53.3		3.7	5.0
3+4 ≤5%	1,386	37.0	37.0	16.1	9.9		786	34.9	54.2		3.3	7.6
3+4 6%-10%	1,426	39.0	35.1	15.7	10.2		839	35.6	51.6		4.8	8.0
3+4 11%-20%	1,136	39.8	37.3	15.1	7.8		689	33.7	46.6		6.4	13.4
3+4 21%-30%	628	41.2	32.5	17.2	9.1		391	34.3	42.5		7.4	15.9
3+4 31%-49%	500	44.0	32.2	13.6	10.2		303	35.3	40.3		10.6	13.9
3+4 Tertiary 5	346	42.2	37.9	10.7	9.3		224	35.3	46.0		6.7	12.1
4+3 50%-60%	409	41.6	35.7	16.1	6.6		257	34.2	36.6		11.7	17.5
4+3 61%-80%	352	48.9	31.5	11.9	7.7		224	34.8	29.5		15.2	20.5
4+3 >80%	79	59.5	15.2	16.5	8.9		50	44.0	34.0		16.0	6.0
4+3 Tertiary 5	485	47.8	34.0	11.8	6.4		338	33.1	33.7		14.8	18.3
≥4+4	383	59.5	26.1	7.3	7.1		271	44.3	24.0		18.1	13.7
Lymph node metastasis						< 0.0001							< 0.0001
N0	5,452	43.7	33.7	13.9	8.8		3176	36.7	43.2		8.6	11.5
N+	526	54.4	28.9	10.3	6.5		355	38.0	22.8		18.9	20.3
Preoperative PSA level (ng/mL)						< 0.0001							< 0.0001
<4	1,212	41.3	33.3	15.7	9.8		681	33.3	46.0		8.5	12.2
4-10	5,952	39.5	35.1	15.5	10.0		3410	34.8	48.6		6.3	10.3
10-20	1,976	45.9	31.0	15.0	8.2		1173	38.4	42.4		8.9	10.3
>20	666	54.2	26.3	11.7	7.8		401	42.9	31.2		11.7	14.2
Surgical margin						0.3059							< 0.0001
Negative	7,893	41.6	33.7	15.1	9.7		4487	36.5	47.0		6.5	10.0
Positive	1,814	44.0	32.6	15.4	8.0		1195	33.9	40.8		11.2	14.1