3.

Hazard ratios (95% confidence intervals) for biochemical relapse after prostatectomy for established risk factors and PSP94/PTEN status

Model		Scenario 4	Scenario 3	Scenario 2	Scenario 1
* P ≤ 0.05, ** P ≤ 0.001, ***P ≤ 0.0001
Variable	Analyzable (n)	5,127	5,206	5,267	3,283
Gleason grade biopsy	≥ 4+4 vs. ≤ 3+3	3.81 (3.25-4.46) ***
cT stage	T2c vs. T1c	2.37 (1.81-3.06) ***	2.27 (1.74-2.91) ***
Preoperative PSA level	≥ 20 vs. < 4	3.46 (2.72-4.42) ***	2.93 (2.30-3.74) ***	2.04 (1.61-2.60) ***	1.95 (1.49-2.61) ***
PSP94/PTEN status	Neg./del. vs. pos./norm.	2.02 (1.70-2.40) ***	1.71 (1.44-2.03) ***	1.49 (1.26-1.77) ***	1.36 (1.13-1.63) *
Gleason grade prostatectomy	≥ 4+4 vs. ≤ 3+3		11.2 (8.83-14.3) ***	6.15 (4.76-7.96) ***	4.51 (3.27-6.29) ***
pT stage	T4 vs. T2			2.98 (2.55-3.48) ***	2.85 (2.38-3.42) ***
Resection margin status	R1 vs. R0			1.41 (1.26-1.59) ***	1.30 (1.13-1.48) **
Nodal stage	N+ vs. N0				1.40 (1.18-1.67) **