S2.
MiRNA and mRNA associations by pathway
| MiRNA | Direction | Apoptosis | Cell cycle | JAK-STAT | MAPK | NFkB | PI3K-AKT | TGFB | p53 | WNT |
| hsa-let-7i-5p | Indirect | YWHAB | TGFBR1 | COL1A2, COL6A3, F2R, ITGAV, THBS2, TNC, YWHAB | INHBA, TGFBR1 | CCND1, CDK1 | SFRP4, SFRP5 | |||
| hsa-miR-106b-5p | Direct | IL10RA | ||||||||
| hsa-miR-106b-5p | Indirect | BIRC5 | BUB3, CCNA2, CCND1, CDC25C, CDK1, MAD2L1, MCM3, MCM4, MCM6, PRKDC, RAD21, YWHAB, YWHAG, YWHAQ | CCND1, PTPN11 | CCND1, ITGA2, YWHAB, YWHAG, YWHAQ | TGIF2 | RRM2 | CCND1 | ||
| hsa-miR-10a-5p | Indirect | ITGA2 | ||||||||
| hsa-miR-1203 | Indirect | CSF2RB | CSF2RB | TGFBR1 | ITGAV | TGFBR1 | ||||
| hsa-miR-124-3p | Indirect | CSF2RB | CSF2RB | DAAM2 | ||||||
| hsa-miR-1243 | Direct | ROCK2 | ||||||||
| hsa-miR-1243 | Indirect | ITGAV | ||||||||
| hsa-miR-1246 | Indirect | BIRC5 | ESPL1, MCM6, MYC, PRKDC, RAD21, RBL1, YWHAB | MYC, PTPN11 | MYC | PLCG1 | BRCA1, MYC, YWHAB | MYC, RBL1, TGIF2 | MYC | |
| hsa-miR-1271-5p | Direct | TRAF5 | ||||||||
| hsa-miR-1291 | Direct | |||||||||
| hsa-miR-1291 | Indirect | ITGA2 | TGIF2 | PERP | ||||||
| hsa-miR-130b-3p | Indirect | CCNA2, ESPL1, MAD2L1, MCM4, PRKDC, YWHAB | PLCG1 | YWHAB | TGIF2 | |||||
| hsa-miR-133b | Indirect | FHL1, LIFR | CXCL12 | CHRM2, TNXB | DAAM2, PRICKLE2 | |||||
| hsa-miR-145-5p | Direct | BIRC5 | MAD2L1, SMC1A | BRCA1 | ||||||
| hsa-miR-145-5p | Indirect | BUB1B, CCNB1, CDC20, CDC25C, CDC6, MCM4, TFDP1 | FHL1, LIFR | PDGFRA | CXCL12 | CHRM2, IGF1, PDGFRA, THBS1, TNXB | TFDP1, THBS1 | CCNB1, GTSE1, IGF1, RRM2, THBS1 | DAAM2, PRICKLE2, SFRP4 | |
| hsa-miR-146a-5p | Indirect | TRAF5 | ||||||||
| hsa-miR-146b-5p | Indirect | STAT1 | F2R, TNC | |||||||
| hsa-miR-150-5p | Direct | BIRC5 | CCNA2, PRKDC | RRM2 | ||||||
| hsa-miR-150-5p | Indirect | BCL2, CSF2RB, ITPR1, PIK3CD, TUBA1B | SMC1A | BCL2, CSF2RB, IL10RA, IL24, IL6R, IL6ST, IL7R, LIFR, PIK3CD, PTPN11 | MAP4K1, MEF2C, PDGFRA, PRKCB, RAC2, RASGRP2, RASGRP3 | BCL2, BTK, CCL21, CD40, CXCL12, PLCG2, PRKCB, ZAP70 | BCL2, CD19, GNG2, GNG7, IL6R, IL7R, ITGA4, PDGFRA, PHLPP2, PIK3CD, PIK3CG | DAAM2, PLCB2, PRKCB, RAC2 | ||
| hsa-miR-151a-3p | Indirect | CDC16, PRKDC, RAD21, YWHAB | YWHAB | TGIF2 | PERP | |||||
| hsa-miR-15a-5p | Indirect | CDC16, RAD21, YWHAB | YWHAB | |||||||
| hsa-miR-17-5p | Direct | IL10RA, IL6R | PDGFRA | TNFRSF11A | PDGFRA, IL6R | |||||
| hsa-miR-17-5p | Indirect | BIRC5 | ANAPC1, CCNA2, CCND1, CDC16, CDC25C, CDK1, CDK4, E2F5, ESPL1, MAD2L1, MCM3, MCM4, MCM6, MYC, PRKDC, RAD21, RBL1, TFDP1, YWHAB, YWHAG, YWHAQ | CCND1, MYC, PTPN11 | HSPA8, MYC | PLCG1 | BRCA1, CCND1, CDK4, GNG4, ITGA2, LAMA5, MYC, YWHAB, YWHAG, YWHAQ | E2F5, MYC, RBL1, TFDP1, TGIF2 | CCND1, CDK1, CDK4, PERP, RRM2 | CCND1, MYC, ROCK2 |
| hsa-miR-1915-5p | Indirect | SFRP5 | ||||||||
| hsa-miR-193b-3p | Direct | DUSP4 | ||||||||
| hsa-miR-193b-3p | Indirect | CTSK | YWHAB | FHL1, LIFR | IL1R1, MEF2C, PDGFRB | CXCL12, IL1R1, TNFRSF11A | COL1A1, COL1A2, COL6A3, CREB3L1, F2R, ITGA11, ITGB5, LAMA5, PDGFRB, THBS2, YWHAB | TGIF2 | PRICKLE2, SFRP4, SFRP5 | |
| hsa-miR-195-5p | Direct | BIRC5 | CDC6, SMC1A | PTPN11 | ||||||
| hsa-miR-195-5p | Indirect | BCL2, TUBA1B | CCNB1, MAD2L1 | BCL2, FHL1, IL10RA, IL6ST, LIFR | MEF2C | BCL2, CCL21, CXCL12, PLCG2 | BCL2 | CCNB1, RRM2 | DAAM2 | |
| hsa-miR-196a-5p | Indirect | ANAPC1, CCNA2, CDC25A, CDC6, MAD2L1, PRKDC, RAD21, YWHAB | YWHAB | TGIF2 | GTSE1, STEAP3 | |||||
| hsa-miR-196b-5p | Direct | TNFRSF10B | TNFRSF11A | CREB3L1 | TNFRSF10B | |||||
| hsa-miR-196b-5p | Indirect | RBL1, YWHAB | DUSP4 | PLCG1 | PHLPP2, SGK2, YWHAB | RBL1, TGIF2 | PLCB4 | |||
| hsa-miR-199a-3p | Indirect | TUBA1B | YWHAB | PDGFRB, TGFBR1 | COL1A1, COL1A2, COL6A3, F2R, ITGA11, ITGAV, ITGB5, PDGFRB, THBS2, TNC, YWHAB | INHBA, TGFBR1 | SFRP4 | |||
| hsa-miR-199a-5p | Direct | TNFRSF11A | ||||||||
| hsa-miR-199a-5p | Indirect | TUBA1B | YWHAB | PDGFRB, TGFBR1 | COL1A1, COL1A2, COL6A3, F2R, ITGA11, ITGAV, ITGB5, PDGFRB, THBS2, TNC, YWHAB | INHBA, TGFBR1 | SFRP4 | |||
| hsa-miR-199b-5p | Indirect | TUBA1B | CDC16, YWHAB | PDGFRB | COL1A1, COL1A2, COL6A3, F2R, ITGA11, ITGB5, PDGFC, PDGFRB, THBS2, TNC, YWHAB | INHBA | PERP | SFRP4 | ||
| hsa-miR-19b-3p | Direct | IL6R | PDGFRA | IL6R, PDGFRA | ||||||
| hsa-miR-19b-3p | Indirect | BIRC5 | ANAPC1, BUB3, CCND1, CDC16, CDC25C, CDK1, ESPL1, MAD2L1, MCM3, MCM4, MCM6, MYC, PRKDC, RAD21, RBL1, TFDP1, YWHAB, YWHAG, YWHAQ | CCND1, MYC, PTPN11 | MYC | BRCA1, CCND1, ITGA2, MYC, YWHAB, YWHAG, YWHAQ | MYC, RBL1, TFDP1, TGIF2 | CCND1, CDK1, PERP, RRM2 | CCND1, MYC, ROCK2 | |
| hsa-miR-203a | Direct | BCL2 | BCL2, LIFR | MEF2C, PDGFRA, PRKCB | BCL2, BTK, PRKCB, PLCG2 | BCL2, GNG2, ITGA4, PDGFRA, PIK3CG | PRKCB | |||
| hsa-miR-203a | Indirect | CCND1, CDC25C, PRKDC, RAD21 | CCND1, IL10RA, IL6R, IL7R, PTPN11 | HSPA8, RAC2 | CCL21 | CCND1, HSP90AA1, HSP90AB1, IL6R, IL7R, ITGA2 | CCND1, PERP | CCND1, RAC2 | ||
| hsa-miR-204-3p | Direct | ROCK2 | ||||||||
| hsa-miR-204-3p | Indirect | ITGAV | ||||||||
| hsa-miR-20a-5p | Direct | IL6R, IL10RA | PDGFRA | IL6R, PDGFRA | ||||||
| hsa-miR-20a-5p | Indirect | BIRC5 | ANAPC1, CCND1, CDC16, CDK4, E2F5, ESPL1, MAD2L1, MCM3, MCM4, MCM6, MYC, PRKDC, RAD21, RBL1, TFDP1, YWHAB, YWHAG, YWHAQ | CCND1, MYC, PTPN11 | MYC | PLCG1 | BRCA1, CCND1, CDK4, GNG4, HSP90AB1, ITGA2, MYC, YWHAB, YWHAG, YWHAQ | E2F5, MYC, RBL1, TFDP1, TGIF2 | CCND1, CDK4, PERP, RRM2 | CCND1, MYC, ROCK2 |
| hsa-miR-20b-5p | Direct | CTSS | IL6R, IL10RA | PDGFRA | BTK, TNFRSF11A | IL6R, PDGFRA | ||||
| hsa-miR-20b-5p | Indirect | BIRC5 | ANAPC1, BUB3, CCNA2, CCND1, CDC16, CDC25C, CDK1, CDK4, MAD2L1, MCM3, MCM4, MCM6, MYC, PRKDC, RAD21, RBL1, TFDP1, YWHAB, YWHAG, YWHAQ | CCND1, MYC, PTPN11 | MYC | CSNK2A2, PLCG1 | BRCA1, CCND1, CDK4, GNG4, ITGA2, MYC, YWHAB, YWHAG, YWHAQ | MYC, RBL1, TFDP1, TGIF2 | CCND1, CDK1, CDK4, PERP, RRM2, STEAP3 | CCND1, CSNK2A2, MYC, ROCK2 |
| hsa-miR-21-3p | Indirect | BIRC5 | PRKDC, RAD21, TFDP1, YWHAB, YWHAG, YWHAQ | PTPN11 | ITGAV, YWHAB, YWHAG, YWHAQ | TFDP1 | PERP, RRM2 | CTNNB1 | ||
| hsa-miR-21-5p | Direct | IL6R | IL6R | |||||||
| hsa-miR-21-5p | Indirect | CCND1, PRKDC, RAD21, YWHAB, YWHAG | CCND1, PTPN11 | TGFBR1 | CCND1, ITGA2, ITGAV, LPAR1, TNC, YWHAB, YWHAG | INHBA, TGFBR1 | CCND1, PERP | CCND1, ROCK2, SFRP5 | ||
| hsa-miR-2117 | Direct | TGFBR1 | ||||||||
| hsa-miR-2117 | Indirect | CSF2RB | CSF2RB, IL6R | IL6R | TGFBR1 | |||||
| hsa-miR-214-3p | Direct | TNFRSF11A | PHLPP1 | |||||||
| hsa-miR-214-3p | Indirect | TUBA1B | IL1R1, PDGFRB, TGFBR1 | IL1R1 | COL1A1, COL1A2, COL6A3, F2R, ITGA11, ITGAV, ITGB5, PDGFRB, THBS2, TNC | INHBA, TGFBR1 | SFRP4 | |||
| hsa-miR-215 | Direct | PLAU | ||||||||
| hsa-miR-215 | Indirect | COL1A1 | ||||||||
| hsa-miR-221-3p | Direct | IL6R | MEF2C | IL6R | ||||||
| hsa-miR-221-3p | Indirect | CASP7 | CCND1, CDK1, MCM3, MCM4, MCM6, PRKDC, RAD21, YWHAB, YWHAG, YWHAQ | CCND1, IL10RA, PTPN11 | HSPA8 | CCL13 | CCND1, HSP90AB1, ITGA2, YWHAB, YWHAG, YWHAQ | TGIF2 | CCND1, CDK1, RRM2, PERP | CCND1, CTNNB1 |
| hsa-miR-222-3p | Indirect | PERP | SFRP5 | |||||||
| hsa-miR-23a-3p | Direct | IL6R | IL6R | |||||||
| hsa-miR-23a-3p | Indirect | PRKDC, YWHAB | TGFBR1 | ITGA2, ITGAV, YWHAB | TGFBR1 | PERP | SFRP5 | |||
| hsa-miR-24-3p | Indirect | PRKDC, YWHAB | TGFBR1 | ITGA2, ITGAV, ITGB5, YWHAB | TGFBR1 | PERP | SFRP5 | |||
| hsa-miR-25-3p | Indirect | BIRC5 | BUB3, CCNA2, CCNB1, CDC25C, CDK1, ESPL1, MAD2L1, MCM3, MCM4, MCM6, PRKDC, RAD21, RBL1, SKP2, YWHAB, YWHAG, YWHAQ | PTPN11 | PLCG1 | BRCA1, YWHAB, YWHAG, YWHAQ | RBL1, TGIF2 | CCNB1, CDK1, RRM2 | ||
| hsa-miR-27a-3p | Direct | IL6R | IL6R | |||||||
| hsa-miR-27a-3p | Indirect | CCND1, PRKDC, RAD21, YWHAB, YWHAG, YWHAQ | CCND1, PTPN11 | CCND1, ITGA2, ITGAV, YWHAB, YWHAG, YWHAQ | CCND1, PERP | CCND1, CTNNB1 | ||||
| hsa-miR-29a-3p | Indirect | PRKDC, RAD21, YWHAB, YWHAQ | TRAF5 | ITGA2, YWHAB, YWHAQ | PERP | ROCK2, SFRP5 | ||||
| hsa-miR-29b-3p | direct | CASP7 | PDGFRA | PDGFRA | ||||||
| hsa-miR-29b-3p | Indirect | CCND1, MCM3, MCM4, PRKDC, RAD21, YWHAB, YWHAG, YWHAQ | CCND1, PTPN11 | HSPA8 | CCND1, ITGA2, YWHAB, YWHAG, YWHAQ | CCND1, PERP | CCND1 | |||
| hsa-miR-30a-5p | Indirect | FHL1, LIFR | TNXB | DAAM2 | ||||||
| hsa-miR-3124-5p | Indirect | CSF2RB, TNFRSF10B | CSF2RB | TNFRSF10B | ||||||
| hsa-miR-32-3p | Indirect | YWHAB | PTPN11 | YWHAB | ||||||
| hsa-miR-324-5p | Direct | CCL13 | ||||||||
| hsa-miR-324-5p | Indirect | PRKDC | PERP | |||||||
| hsa-miR-330-3p | Indirect | TNFRSF11A | ||||||||
| hsa-miR-331-3p | Indirect | TGFBR1 | LAMA5 | TGFBR1 | ||||||
| hsa-miR-34a-5p | Indirect | PRKDC, RAD21, YWHAB | PTPN11 | CCL13 | ITGA2, ITGAV, YWHAB | PERP | ||||
| hsa-miR-3591-3p | Direct | SFRP5 | ||||||||
| hsa-miR-361-5p | Indirect | CDC16, PRKDC, YWHAB | TNFRSF11A | YWHAB | TGIF2 | SFRP5 | ||||
| hsa-miR-3651 | Direct | IL6R | IL6R | |||||||
| hsa-miR-3651 | Indirect | CDK4, MYC, PRKDC, RAD21, RBL1, YWHAB, YWHAG, YWHAQ | IL10RA, MYC, PTPN11 | MYC | CDK4, GNG4, ITGA2, MYC, YWHAB, YWHAG, YWHAQ | MYC, RBL1, TGIF2 | CDK4, PERP | MYC, ROCK2, SFRP5 | ||
| hsa-miR-365a-3p | Direct | TNFRSF11A | ||||||||
| hsa-miR-365a-3p | Indirect | PRKDC | ITGB5, TNXB | GTSE1 | ||||||
| hsa-miR-375 | Direct | YWHAB | PLCG1 | THBS2, YWHAB | TGIF2 | |||||
| hsa-miR-375 | Indirect | MYC | MYC | MYC | TNFRSF11A | COL1A1, CREB3L1, MYC | MYC | MYC | ||
| hsa-miR-378g | Indirect | TRAF5 | SFRP5 | |||||||
| hsa-miR-3923 | Indirect | CTSS | TRAF5 | |||||||
| hsa-miR-3976 | Indirect | TNXB | ||||||||
| hsa-miR-424-3p | Direct | CDC6 | ||||||||
| hsa-miR-424-3p | Indirect | YWHAB, YWHAE | OSM | DUSP4 | PLCG1, TNFRSF11A | CREB3L1, GNG4, OSM, YWHAB, YWHAE | TGIF2 | |||
| hsa-miR-425-5p | Indirect | BIRC5 | PRKDC, RAD21, YWHAB, YWHAQ | PTPN11 | BRCA1, COMP, YWHAB, YWHAQ | TGIF2 | ||||
| hsa-miR-4251 | Indirect | ITGAV | SFRP5 | |||||||
| hsa-miR-429 | Direct | IL10RA | RASGRP3 | PLCG2 | ||||||
| hsa-miR-429 | Indirect | PRKDC, RAD21 | ||||||||
| hsa-miR-4315 | Indirect | CSF2RB | CSF2RB | CTNNB1 | ||||||
| hsa-miR-4421 | Indirect | SFRP5 | ||||||||
| hsa-miR-4469 | Indirect | CSF2RB | CSF2RB | |||||||
| hsa-miR-4638-3p | Indirect | SFRP5 | ||||||||
| hsa-miR-4749-3p | Direct | TGIF2 | ||||||||
| hsa-miR-4749-3p | Indirect | YWHAB | YWHAB | ROCK2 | ||||||
| hsa-miR-483-3p | Indirect | TGIF2 | ||||||||
| hsa-miR-497-5p | Indirect | IL6ST, LIFR | CCL21, CXCL12 | LPAR1, TNXB | DAAM2 | |||||
| hsa-miR-5008-3p | Indirect | SFRP5 | ||||||||
| hsa-miR-501-3p | Direct | CTSS | PDGFRA | PDGFRA | ||||||
| hsa-miR-501-3p | Indirect | CDC25C, MAD2L1, MYC, PRKDC, YWHAB | MYC | MYC | GNG4, ITGA2, MYC, YWHAB | MYC, TGIF2 | PERP | MYC | ||
| hsa-miR-518c-5p | Indirect | CNTF, IL6R | IL6R | |||||||
| hsa-miR-520d-3p | Indirect | TRAF5 | ||||||||
| hsa-miR-525-5p | Indirect | CSF2RB | CSF2RB | |||||||
| hsa-miR-5685 | Indirect | TRAF5 | SFRP5 | |||||||
| hsa-miR-583 | Indirect | MAD2L1, MYC, SMC1A | MYC | MYC | PLCG1 | MYC | MYC, TGIF2 | STEAP3 | MYC | |
| hsa-miR-590-5p | Direct | TNFRSF11A | ||||||||
| hsa-miR-6071 | Direct | TGFBR1 | ITGAV | |||||||
| hsa-miR-6071 | Indirect | TGFBR1 | ||||||||
| hsa-miR-650 | Direct | BIRC5 | MAD2L1 | PTPN11 | ITGA2 | PERP, RRM2 | ||||
| hsa-miR-650 | Indirect | BCL2, CSF2RB, ITPR1, PIK3CD | CCNA2, MCM4, PRKDC, RAD21, YWHAG, YWHAH | BCL2, CSF2RB, IL10RA, IL6R, IL6ST, IL7R, LIFR, PIK3CD | MAP4K1, MEF2C, PDGFRA, PRKCB, RAC2, RASGRP2, RASGRP3 | BCL2, BTK, CCL21, CD40, PLCG2, PRKCB | BCL2, BRCA1, GNG2, GNG7, IL6R, IL7R, ITGA4, PDGFRA, PIK3CD, PIK3CG, YWHAG, YWHAH | PLCB2, PRKCB, RAC2 | ||
| hsa-miR-6515-5p | Direct | YWHAB | YWHAB | |||||||
| hsa-miR-6515-5p | Indirect | CSNK2A2 | CREB3L1, HSP90AB1 | CSNK2A2, ROCK2 | ||||||
| hsa-miR-663a | Indirect | MYC, YWHAB | MYC | MYC | GNG4, MYC, YWHAB | MYC | MYC, ROCK2 | |||
| hsa-miR-663b | Direct | TNFRSF11A | PHLPP1 | |||||||
| hsa-miR-663b | Indirect | MYC, PRKDC, RBL1, YWHAB | MYC | MYC | PLCG1 | GNG4, HSP90AB1, ITGA2, MYC, YWHAB | MYC, RBL1, TGIF2 | PERP | MYC, PLCB4, ROCK2 | |
| hsa-miR-6716-3p | Indirect | SFRP5 | ||||||||
| hsa-miR-92a-3p | Direct | CSF2RB | CSF2RB | |||||||
| hsa-miR-92a-3p | Indirect | BCL2L1 | ANAPC1, CDC16, MYC, PRKDC, RAD21, RBL1, TFDP1, YWHAB, YWHAQ | BCL2L1, IL6R, MYC, PTPN11 | MYC | BCL2L1, CSNK2A2, PLCG1, TNFRSF11A, TRAF5 | BCL2L1, BRCA1, CREB3L1, GNG4, IL6R, ITGA2, MYC, YWHAB, YWHAQ | MYC, TFDP1, TGIF2, RBL1 | PERP | CSNK2A2, MYC, PLCB4, ROCK2 |
| hsa-miR-93-5p | Direct | IL10RA | ||||||||
| hsa-miR-93-5p | Indirect | BIRC5 | ANAPC1, BUB1, BUB3, CCNA2, CCNB1, CCND1, CDC25C, CDC6, CDK1, CDK4, ESPL1, MAD2L1, MCM3, MCM4, MCM6, PRKDC, RAD21, RBL1, SKP2, YWHAB, YWHAG, YWHAQ | CCND1, PTPN11 | HSPA8 | BRCA1, CCND1, CDK4, ITGA2, YWHAB, YWHAG, YWHAQ | TGIF2, RBL1 | CCNB1, CCND1, CDK1, CDK4, RRM2 | CCND1, ROCK2 | |
| hsa-miR-934 | Direct | TNFRSF11A | ||||||||
| hsa-miR-934 | Indirect | TUBA1B | OSM | PDGFRB | PLAU | COL1A1, COL1A2, COL6A3, COMP, F2R, ITGA11, ITGAV, ITGB5, OSM, PDGFC, PDGFRB, THBS2, TNC | INHBA | SFRP4 | ||
| hsa-miR-99a-5p | Indirect | LIFR | ITGA11, ITGB5, PDGFC, TNXB | GTSE1, RRM2 | SFRP4 |