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. 2019 May;16(2):234–246. doi: 10.20892/j.issn.2095-3941.2018.0284

4.

(A, B) Growth of tumour cells injected subcutaneously into the back of BALB/c nude mice, treated as indicated with either; vehicle; 0.1 mg/kg talazoparib; radiation (2 x 5 Gy); or 0.1 mg/kg talazoparib 1 hour prior to each of 2 x 5 Gy radiation doses. Treatment with talazoparib+radiation significantly slowed tumor growth for (A) DLD1 cells but not (B) RKO cells. (C, D) Representative images of tumours harvested from the vehicle treated group (at 400 mm<sup>3</sup>) show similar histology for both (C) DLD1 and (D) RKO xenografts including perinecrotic hypoxia (CA9 staining, brown) and tumor necrosis (N).

Talazoparib significantly enhances the response of colorectal cancer cells grown in vivo to ionizing radiation.