S1.

Details of the cell lines

Cell line	BRAF	KRAS	PIK3CA	P53	MSI/MSS	CIMP
Table of cell lines comprising the panel for screen validation: Data is from Mouradov et al., Cancer Res. 2014; 74: 3238-47, except where indicated. † Indicates data from Prof. Walter Bodmer, personal communication. na. Indicates information not available
C10	WT	WT	WT	WT	MSS	CIMP-
C99	WT	WT	WT	WT	MSS	CIMP-
CCK81	WT	WT	C420R, C472Y	P278H	MSI	CIMP-
COLO678	WT	G12D	WT	WT	MSS	CIMP+
CW2 †	WT	P140H	P283S	WT	MSI	na.
DLD1	WT	G13D	E545K	S241F	MSI	CIMP+
HCA7	WT	WT	WT	P301fs*44	MSI	CIMP+
HT29	V600E	WT	WT	R273H	MSS	CIMP+
HT55	V600E	WT	WT	.R213L	MSS	CIMP-
LS411	V600E	WT	WT	Y126*	MSI	CIMP+
OXCO4 †	V600E	WT	WT	mutant	MSS	na.
RKO	V600E	WT	H1047R	WT	MSI	CIMP+
SW1222	WT	A146V	WT	WT	MSS	CIMP-
SW403	WT	G12V	Q546K	E51*	MSS	CIMP-
VACO5 †	WT	WT	H1047R	mutant	MSI	na.