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. 2019 May;16(2):288–298. doi: 10.20892/j.issn.2095-3941.2018.0309

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Copyright 2019 Cancer Biology & Medicine

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Therapeutic effects of CD8⁺ T cells from immunized mice on subcutaneously inoculated A549 cell tumors in nude mice. (A) Inoculation schedule for nude mice and adoptive transfer of CD8⁺ T cells from immunized HLA-A2 transgenic mice. (B) Representative image and (C) statistical analysis of luminescence intensity in tumor-bearing nude mice who received CD8⁺ T cells purified from control, GAS-, or GAS/MAGE-A3-immunized HLA-A2 transgenic mice. (D) Representative images and (E) statistical analysis (size) of tumors removed from nude mice 32 d after adoptive transfer of CD8⁺ T cells from control, GAS-, or GAS/MAGE-A3-immunized HLA-A2 transgenic mice. (F) Survival curves for tumor-bearing nude mice treated with CD8⁺ T cells from control, GAS-, or GAS/MAGE-A3-immunized HLA-A2 transgenic mice. ^** P ≤ 0.01.