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Simulated effects of Orai block on the pacemaker activity, IOrai, IClCa, INaCa, [Ca2+]i, and [Ca2+]rel in current-clamp mode. The block of Orai conductance was simulated by removal of conductance after 7 s. Resting membrane potential is slightly hyperpolarized by block of Orai. All the oscillatory activities are abolished.
