Fig. 4.

Effects of the concomitant administration of VEGFA and antibodies against anti-sFlt1 on hepatic damage and regeneration 24 h after surgery and survival rate in Ob Zucker rats. A Hepatic injury (plasma AST, ALT, and GLDH levels; damage score and representative photomicrograph of necrosis (× 10)). B Hepatic function (ALP and bilirubin levels). C Endothelial function (vWF and HA levels). D Lipid peroxidation (MDA levels) and neutrophil accumulation (MPO levels). E Hepatic regeneration (percentage of Ki67 positive-hepatocytes and representative photomicrograph of Ki67 immunohistochemical positivity (× 10); cyclin D1, E, and A levels). Survival of Ob Zucker animals was monitored (postoperative day 14) (E). +P < 0.05 versus PH+I/R