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. 2019 Aug 28;9:12465. doi: 10.1038/s41598-019-48875-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Double knockdown of GM130/Golgin45, but not GRASP65/55 results in intercisternal membrane fusion between neighboring Golgi cisternae. Representative EM micrograph of HeLa cells treated with siRNAs against GM130/Golgin45 siRNA for 96 hrs (scale bar = 0.5 μm). Double knockdown of the two Syntaxin5-binding Golgins resulted in significant intercisternal fusion among the Golgi cisterna, as indicated by tracing lines for Golgi membranes in the inset. In this photo, at least 3–4 Golgi cisterna have fused with one another to form a Golgi stack with extensively continuous luminal space. M = mitochondria, N = nucleus, G = Golgi apparatus.