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. 2019 Aug 28;5:13. doi: 10.1038/s41537-019-0081-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — MAP2-IR is reduced uniformly in V1, LIP, and DLPFC of SZ patients compared with matched NPC subjects. a Estimated marginal means of log_e(MAP2-IR) grayscale intensity levels by diagnostic group and cortical region. MAP2-IR differed significantly between groups and between regions, but there was not a significant diagnosis by region effect. N = V1: 19/20 (SZ/NPC); LIP: 20/20; DLPFC: 20/19. Error bars = SEM. ***p < 0.001 (diagnosis effect). p < 0.001 (region effect). b Tukey boxplots by diagnostic group of log_e(MAP2-IR) levels averaged across region. N = 18 subjects per group. c–e Control and SZ log_e(MAP2-IR) levels in V1 (c), LIP (d), and DLPFC (e) shown by pair relative to a y = x line of no change. N = 18 pairs. Exemplary micrographs from a pair in LIP (filled dot in d) are shown in Fig. 2. f Tukey boxplots of log_e(MAP2-IR) pairwise ratios (SZ:NPC) by region. N = 18 pairs per region. AU = arbitrary units

Inline graphic — MAP2-IR is reduced uniformly in V1, LIP, and DLPFC of SZ patients compared with matched NPC subjects. a Estimated marginal means of log_e(MAP2-IR) grayscale intensity levels by diagnostic group and cortical region. MAP2-IR differed significantly between groups and between regions, but there was not a significant diagnosis by region effect. N = V1: 19/20 (SZ/NPC); LIP: 20/20; DLPFC: 20/19. Error bars = SEM. ***p < 0.001 (diagnosis effect). p < 0.001 (region effect). b Tukey boxplots by diagnostic group of log_e(MAP2-IR) levels averaged across region. N = 18 subjects per group. c–e Control and SZ log_e(MAP2-IR) levels in V1 (c), LIP (d), and DLPFC (e) shown by pair relative to a y = x line of no change. N = 18 pairs. Exemplary micrographs from a pair in LIP (filled dot in d) are shown in Fig. 2. f Tukey boxplots of log_e(MAP2-IR) pairwise ratios (SZ:NPC) by region. N = 18 pairs per region. AU = arbitrary units