Table 2.
Top five pathways enriched by targets of each herb in SZRP.
| Species name | Herbal group | Pathway name | KEGG ID | Ratio (%) | −Log(p-value) |
|---|---|---|---|---|---|
|
Ziziphus jujuba var. spinosa
(Bunge) Hu ex H.F.Chow |
Emperor (Jun) | Serotonergic synapse | hsa04726 | 12.5 | 11.09 |
| Dopaminergic synapse | hsa04728 | 10 | 7.7 | ||
| Amphetamine addiction | hsa05031 | 7.5 | 6.82 | ||
| Adrenergic signaling in cardiomyocytes | hsa04261 | 8.75 | 6.09 | ||
| Cocaine addiction | hsa05030 | 6.25 | 6.08 | ||
| Anemarrhena asphodeloides Bunge | Minister (Chen) | Fluid shear stress and atherosclerosis | hsa05418 | 8.81 | 16.73 |
| AGE-RAGE signaling pathway | hsa04933 | 6.17 | 11.88 | ||
| Influenza A | hsa05164 | 7.49 | 11.67 | ||
| Ovarian steroidogenesis | hsa04913 | 4.85 | 11.65 | ||
| Adipocytokine signaling pathway | hsa04920 | 5.29 | 11.36 | ||
| Wolfiporia extensa (Peck) Ginns | Minister (Chen) | Hepatitis B | hsa05161 | 13.66 | 25.55 |
| Influenza A | hsa05164 | 13.11 | 22.1 | ||
| AGE-RAGE signaling pathway | hsa04933 | 9.84 | 18.85 | ||
| Chagas disease (American trypanosomiasis) | hsa05142 | 9.84 | 18.6 | ||
| Hepatitis C | hsa05160 | 10.38 | 17.93 | ||
| Ligusticum sinense Oliv. | Adjuvant (Zuo) | AGE-RAGE signaling pathway | hsa04933 | 9.18 | 27.63 |
| Hepatitis B | hsa05161 | 9.86 | 25.51 | ||
| Fluid shear stress and atherosclerosis | hsa05418 | 8.84 | 21.77 | ||
| Chagas disease (American trypanosomiasis) | hsa05142 | 7.14 | 18.79 | ||
| Prolactin signaling pathway | hsa04917 | 6.12 | 18.05 | ||
| Glycyrrhiza uralensis Fisch. | Courier (Shi) | AGE-RAGE signaling pathway | hsa04933 | 14 | 33.98 |
| Fluid shear stress and atherosclerosis | hsa05418 | 15 | 32.19 | ||
| Th17 cell differentiation | hsa04659 | 11.5 | 24.88 | ||
| IL-17 signaling pathway | hsa04657 | 11 | 24.81 | ||
| Hepatitis B | hsa05161 | 11.5 | 21.73 |