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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Brain Struct Funct. 2019 Jul 19;224(7):2525–2535. doi: 10.1007/s00429-019-01921-w

Figure 6. Chemogenetic stimulation of mesolimbic pathway increases wakefulness.

Figure 6.

A. Typical examples of polygraphic recordings and corresponding hypnograms and FFT delta power following vehicle or CNO (0.2 mg/kg, i.p. at 9 a.m.) administration in a rat with hM3Dq receptors in the mesolimbic dopamine neurons (black, wakefulness; red, REM sleep; yellow, NREM sleep).

B. Time course of wake, REM and NREM sleep produced by saline or CNO (0.2 mg/kg) injection at 9 a.m. or at 9 p.m. Data is shown by hourly mean ± SEM of wake, REM and NREM sleep. *p < 0.05; **p < 0.01.