Table 2.

Diagnosis of Neurosarcoidosis

Diagnosis	Criteria	Additional comments
Definite	Suggestive clinical presentation of neurosarcoidosis	None
	Plus
	Positive histology of nervous system	Presence of sarcoid-type granulomas with epithelioid cells and macrophages without necrosis in the center, surrounded by lymphocytes, plasma cells, and mast cells in tissue biopsied from nervous system
	Plus
	Exclusion of other possible diagnoses	None
Probable	Suggestive clinical presentation of neurosarcoidosis	None
	Plus
	Evidence of inflammation in central nervous system	Elevated protein and/or cells and/or oligoclonal band in cerebrospinal fluid OR Abnormalities on brain magnetic resonance imaging compatible with neurosarcoidosis
	Plus
	Evidence of systemic sarcoidosis	Presence of sarcoid-type granulomas with epithelioid cells and macrophages without necrosis in the center, surrounded by lymphocytes, plasma cells, and mast cells in tissue biopsied from extraneural organs OR At least 2 indirect evidences from gallium scan, chest imaging, and elevated angiotensin-converting enzyme level
	Plus
	Exclusion of other possible diagnoses	None
Possible	Suggestive clinical presentation of neurosarcoidosis with exclusion of other diseases when the criteria for definite and probable diagnosis are not met	None

Data from QJM.⁴⁷