FIGURE 2.

Sputum type-2 innate lymphoid cells (ILC2s) were higher in severe therapy-resistant asthma (STRA) than difficult asthma (DA), but interleukin (IL)-17⁺ cells were similar. a) Induced sputum frequency of i) CRTH2⁺ ILCs (Lin^negCD45⁺) and ii) CD4⁺ T-cells (CD4⁺CD3⁺) from children with STRA, DA and with recurrent lower respiratory tract infections (chronic inflammation (CI)); frequency of b) IL-4⁺ and c) IL-13⁺ ILCs and d) IL-17⁺ ILCs and CD4⁺ T-cells. Kruskall–Wallis test with a Dunn's post-test, followed by Mann–Whitney test between indicated pairs of groups. *: p<0.05, ***: p<0.001. STRA n ≥9, DA n ≥4 and CI n ≥6.