Figure 12.

Inhibition of xCT in reprogramming chief cells results in apoptosis. Immunostained sections from untreated (n = 4), L635-treated (n = 4), and L635 + sulfasalazine–treated (n = 3) C57Bl/6J mice killed after 3 days of L635 treatment for apoptosis marker cleaved caspase-3 (red), zymogenic granule marker GIF (green), with nuclear counterstain 4′,6-diamidino-2-phenylindole (DAPI) (blue). Scale bars: 100 μm. Magnified inset of chief cell region with arrows indicating cleaved caspase-3 and GIF dual-positive apoptotic chief cells.