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. 2019 Aug 22;10:1982. doi: 10.3389/fimmu.2019.01982

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Copyright © 2019 Morrow, Coopersmith and Ford.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The proposed role of the IL-17, IL-27, and IL-33 axis during sepsis. Th17 cells that receive co-inhibitory signaling from IL-27 induced Tr1 cells have inhibited production of IL-17. Differentiation of naïve T cells into Th17 cells is also inhibited by IL-27 through the modulation of DC cytokine production. ILC2 cells and EOs expansion are also inhibited through the action of IL-27 signaling on IL-33. Th17, T helper type 17 cell; Tr1, T regulatory type 1 cell; ILC2, innate lymphocyte type 2 cell; DC, dendritic cell; EO, eosinophil.