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. 2019 Jul 25;8(1):1108–1121. doi: 10.1080/22221751.2019.1637072

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Tumour growth patterns resulting from IV infection with CRPV virions via marginal ear vein injection. (A) Tumour growth on one (NZW#1) of the three animals at week 11 post infection is shown. (B) one (NZW#3) of the four additional rabbits (NZW#3-6) infected by IV injection of virions equivalent to 5.5 × 10⁹ viral DNA equivalents. All developed tumours at six weeks post infection. Both tumours (A and B) exhibited an appearance similar to tumours from local skin tumours initiated with high to low dilutions of virus at week six post infection (C). (D, F) The tumours induced via marginal ear vein (IV) infection have similar morphology and histology (H&E, 20×) to those (H) initiated by local infections (H&E, 20×). Viral DNA was detected by in situ hybridization (ISH) in tumours induced by both intravenous (E, G) and local skin infections (I, 20×, arrows).