Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Arch Toxicol. 2019 Jun 15;93(7):1893–1902. doi: 10.1007/s00204-019-02486-7

Fig. 4: 4-ABP and AαC bioactivation by CYP2A6 and CYP2A13.

Fig. 4:

4-ABP and AαC (10 μM) were incubated with human recombinant CYP2A6 and CYP2A13 for 30 min at 37 °C. The formed HONH-4-ABP and HONH-AαC or the synthetic HONH-4-ABP and HONH-AαC were then incubated with CT-DNA at pH 5, for 30 min. 4-ABP and AαC DNA adducts were measured by UPLC-ESI/MS3. (Three independent experiments,*P <0.05; **P <0.01, ***P <0.005). ND: not detected.