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. 2019 Aug 28;17:294. doi: 10.1186/s12967-019-2035-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Kaplan-Meier analysis of OS (a, b) and PFS (c, d) for stage IV NSCLC kinetic cohort. Patients are stratified according to HD-CTC dynamics, into three groups (a and c): increase, stable, or decrease, or into two groups (b and d) where stable and decreasing patients are combined. Significant benefit in terms of increased OS and PFS for patients displaying an increasing number of HD-CTCs (P-value < 0.05)