Table 4.
Comparisons of Clinical characteristics between quinolone-susceptible and quinolone-resistant groups
| Factors | Susceptible group N = 86 | Resistant group N = 39 | p value |
|---|---|---|---|
| Age, years | 63.0 (51.0–70.0) | 66.0 (53.5–72.5) | 0.215 |
| Age ≥ 65 years, n(%) | 37 (43.0) | 20 (51.3) | 0.390 |
| Gender, male | 57 (66.3) | 29 (64.6) | 0.233 |
| Comorbidities | |||
| HTN | 30 (34.9) | 16 (41.0) | 0.509 |
| DM | 29 (33.7) | 10 (25.6) | 0.366 |
| Cardiovascular disease | 13 (15.1) | 9 (23.1) | 0.279 |
| Chronic kidney disease | 6 (7.0) | 2 (5.1) | 1.000 |
| End stage renal disease | 4 (4.7) | 4 (10.3) | 0.255 |
| Chronic liver disease | 12 (14.0) | 4 (10.3) | 0.774 |
| Pulmonary disease | 8 (9.3) | 4 (10.3) | 1.000 |
| Solid tumor | 42 (48.8) | 19 (48.7) | 0.990 |
| Hematologic malignancy | 12 (14.0) | 6 (15.4) | 0.833 |
| Solid organ transplantation | 5 (5.8) | 2 (5.1) | 1.000 |
| Charlson score | 6.1 ± 3.1 | 7.4 ± 3.2 | 0.030 |
| Predisposing factors | |||
| Chemotherapy | 11 (12.8) | 3 (7.7) | 0.546 |
| Major surgerya | 28 (32.9) | 16 (35.4) | 0.382 |
| ICU care | 54 (62.8) | 29 (74.4) | 0.205 |
| Hospital stay before bacteremia, days | 17.0 (8.0–34.0) | 30.0 (13.5–57.5) | 0.015 |
| Central venous catheter | 57 (66.3) | 32 (84.2) | 0.019 |
| Hemodialysis catheter | 9 (10.5) | 8 (21.6) | 0.100 |
| Mechanical ventilator | 36 (41.9) | 24 (63.2) | 0.029 |
| Foley catheter | 47 (54.7) | 28 (73.7) | 0.046 |
| Clinical findings | |||
| Shock | 23 (26.7) | 20 (51.3) | 0.007 |
| APACHE II score | 13.0 (8.0; 18.0) | 14.0 (11.0; 21.5) | 0.115 |
| Laboratory findings | |||
| Neutropenia | 14 (16.3) | 4 (10.3) | 0.374 |
| Hypoalbuminemia | 52 (60.5) | 21 (53.8) | 0.487 |
| Thrombocytopenia | 28 (32.6) | 19 (48.7) | 0.084 |
| Hemoglobin, g/L | 9.8 ± 1.7 | 9.4 ± 1.3 | 0.296 |
| C-reactive protein, mg/L | 86.8 (41.5–142.5) | 79.3 (44.5–153.0) | 0.914 |
| Estimated GFR, ml/min per 1.73m2 | 87.0 (51.0–101.0) | 72.0 (45.4–106.0) | 0.592 |
| Outcomes | |||
| Inappropriate antimicrobial therapy | 23 (26.7) | 16 (42.1) | 0.089 |
| Hospital stay, days | 50.0 (26.0–78.0) | 68.0 (35.0–150.0) | 0.054 |
| Mortality | 48 (55.8) | 34 (87.2) | 0.001 |
Note. HTN Hypertension, DM Diabetes mellitus, ICU Intensive care unit, APACHE II Acute Physiologic and Chronic Health Evaluation II score
The data were expressed as mean ± standard deviation, number (%), or median (interquartile range)
a Major surgery, any surgical procedure that involves anesthesia or respiratory assistance