Figure 3.

Local administration of MSCs during partial hepatectomy reduces collagen content of regenerating livers in a fibrotic mouse model. After induction of fibrosis mice received local 2 x 10⁶ MSC treatment or underwent pHx and local treatment with vehicle, 1 x 10⁶ or 2 x 10⁶ MSCs (N = 15 per group). A, Normalized body weight during regeneration. B, Normalized liver weight and (C) relative weights of treated and untreated lobes as percentage liver after regeneration. D, Sirius‐red stained sections of resected, untreated and treated remaining liver lobe tissue of the different treatment groups (20x magnifications). E, Reduction of Sirius‐red staining relative to resected tissue. F, Estimated lobuli closure. Data are expressed as mean ± SEM. **P ≤ 0.01, ***P ≤ 0.001. MSCs, mesenchymal stromal cells; pHx, partial hepatectomy