Table 1.
Cardiac morphology, haemodynamics and echocardiographic data 4 weeks after MI
| Parameters | Sham | Infarction | ||||
|---|---|---|---|---|---|---|
| Young | Ageing | Young‐Veh | Young‐BP | Ageing‐Veh | Ageing‐BP | |
| No. of rats | 10 | 10 | 9 | 12 | 8 | 8 |
| Body weight, g | 352 ± 16 | 588 ± 18* | 342 ± 16 | 358 ± 18 | 545 ± 18 ‡ | 564 ± 14 ‡ |
| Heart rate, bpm | 374 ± 12 | 348 ± 22 | 388 ± 15 | 402 ± 21 | 342 ± 27 | 352 ± 27 |
| LVESP, mm Hg | 98 ± 7 | 104 ± 5 | 94 ± 8 | 101 ± 7 | 99 ± 9 | 100 ± 7 |
| LVEDP, mm Hg | 6 ± 1 | 5 ± 3 | 19 ± 5 | 16 ± 5 | 20 ± 5 | 16 ± 5 |
| +dP/dt, mm Hg/s | 7071 ± 352 | 7342 ± 398 | 2873 ± 331 | 3376 ± 329 † | 2682 ± 372 | 2872 ± 307 |
| −dP/dt, mm Hg/s | 6872 ± 339 | 6092 ± 286* | 2106 ± 239 | 2582 ± 307 † | 2017 ± 212 | 2431 ± 233 † |
| Infarct size, % | – | – | 40 ± 2 | 41 ± 3 | 41 ± 3 | 41 ± 2 |
| LVW/BW, mg/g | 2.22 ± 0.21 | 2.35 ± 0.25 | 3.55 ± 0.31 | 3.39 ± 0.38 | 3.69 ± 0.42 | 3.45 ± 0.40 |
| LVEDD (mm) | 6.1 ± 0.2 | 6.4 ± 0.2* | 8.9 ± 0.3 | 7.6 ± 0.2 † | 9.6 ± 0.3 ‡ | 8.5 ± 0.2 ‡ |
| LVESD (mm) | 3.7 ± 0.2 | 4.0 ± 0.2* | 7.2 ± 0.2 | 5.6 ± 0.3 † | 7.8 ± 0.3 ‡ | 6.4 ± 0.3 † , ‡ |
| FS (%) | 39 ± 3 | 38 ± 3 | 19 ± 3 | 26 ± 3 † | 18 ± 4 | 25 ± 3 † |
Values are mean ± SD.
Abbreviations: BP, n‐butylidenephthalide; BW, body weight; LW, lung weight; LVEDD, left ventricular end‐diastolic dimension; LVEDP, left ventricular end‐diastolic pressure; LVESD, left ventricular end‐systolic dimension; LVESP, left ventricular end‐systolic pressure; LVW, left ventricular weight.
*
P < 0.05 compared with young sham.
†
P < 0.05 vs vehicle in respective age group.
‡
P < 0.05 vs the same treatment in the young group.