Figure 8.

Molecular mechanisms of lncRNA H19 involved in lung adenocarcinoma by promoting methylation of CDH1 promoter. LncRNA H19 is highly expressed in lung adenocarcinoma. LncRNA H19 recruits methyltransferases DNMT1 and DNMT3A to CDH1 promoter region, which leads to up‐regulation of the expression of CDH1D, thereby promoting proliferation and EMT while inhibiting apoptosis of lung adenocarcinoma cells. lncRNA H19, long non‐coding RNA H19; CDH1, E‐cadherin; DNMT1, DNA methyltransferase 1; DNMT3A, DNA methyltransferase 3A; EMT, epithelial‐mesenchymal transition