Table 2.
Clinical studies investigating miR‐125b in patients with vascular diseases
| Articles | Sample size | Origin | Categorization | Disease type | Relationship | Reference |
|---|---|---|---|---|---|---|
| Huang et al. (2014) | 676 | Plasma | Low vs High miR‐125b | Acute myocardial infarction | OR 4.27 for disease (2.84‐6.41) | 52 |
| Liu et al. (2014) | 12 | Tissue | Disease vs control samples | Intracranial aneurysm | FC 0.29 (P = .04) | 53 |
| Sepramaniam et al. (2014) | 287 | Whole blood | Disease vs control samples | Acute stroke | FC 1.795 (P = .007) | 54 |
| Ding et al. (2015) | 124 | Plasma | Disease vs control samples | Coronary heart disease | FC 0.778 (P = .055) | 60 |
| Marques et al. (2016) | 17 | Plasma (coronary sinus) | Disease vs control samples | Congestive heart failure | FC 0.27 (P = .023) | 62 |
| Jia et al. (2016) | 309 | Plasma | Disease vs control samples | Acute coronary syndrome | FC 4.46 (P = .008) | 63 |
| Bo et al. (2017) | 61 | Whole blood | Disease vs control samples | Intracranial aneurysm | Predicted to be altered | 67 |
| Tiedt et al. (2017) | 380 | Plasma | Disease vs control samples | Acute ischaemic stroke | FC 2.54 (P < .0001) | 69 |
| Chao et al. (2017) | 223 | Serum | Low vs High (/control) | Vascular calcification |
OR 1.41 for disease (P = .03) HR 7.14 for progression (P < .01) |
70 |
| Courtois et al. (2018) | 57 | Plasma | Disease vs control samples | Abdominal aortic aneurysm | Lower (P < .05) | 74 |
| Gui et al. (2018) | 205 | Serum | Disease vs control samples | Acute ischaemic stroke | FC 1.372 (P = .019) | 76 |
| Kay et al. (2019) | 121 | Plasma | Disease vs control samples | Coronary or carotid atherosclerosis | Lower | 78 |
Abbreviations: FC, fold change; HR, hazard ratio; OR, odds ratio.