Table 1.
Differentially expressed mRNAs in IDD patients and normal controls in both the training set and the validation set
| mRNA | Training set | Validation set | ||
|---|---|---|---|---|
| Fold change | P value | Fold change | P value | |
| Up‐regulated | ||||
| FGF9 | 4.1 | 0.23 | ‐ | ‐ |
| SIRT1 | 7.4 | 0.006 ** | 7 | 0.15 |
| STXBP4 | 4.1 | 0.32 | ‐ | ‐ |
| FBXO33 | 8.9 | 0.34 | ‐ | ‐ |
| SNX19 | 7.5 | 0.09 | ‐ | ‐ |
| ADAMTS5 | 6.1 | 0.34 | ‐ | ‐ |
| EZH1 | 7.3 | 0.45 | ‐ | ‐ |
| SHANK2 | 6.2 | 0.38 | ‐ | ‐ |
| SLC7A6 | 7.6 | 0.27 | ‐ | ‐ |
| PCDH10 | 6.6 | 0.004 ** | 6.2 | 0.32 |
| COL7A1 | 8.2 | 0.78 | ‐ | ‐ |
| HSPH1 | 7.1 | 0.29 | ‐ | ‐ |
| Rux2 | 4.7 | 0.13 | ‐ | ‐ |
| C6orf106 | 6.2 | 0.07 | ‐ | ‐ |
| Down‐regulated | ||||
| MMP13 | 0.19 | 0.14 | ‐ | ‐ |
| KLF2 | 0.18 | 0.26 | ‐ | ‐ |
| CXCR5 | 0.31 | 0.87 | ‐ | ‐ |
| IGFBP5 | 0.02 | 0.002 ** | 0.031 | 0.005 ** |
| SNX21 | 0.11 | 0.43 | ‐ | ‐ |
| DDX5 | 0.37 | 0.35 | ‐ | ‐ |
| RNF34 | 0.21 | 0.56 | ‐ | ‐ |
| PIK3CA | 0.18 | 0.006 ** | 0.11 | 0.32 |
| E2F3 | 0.12 | 0.43 | ‐ | ‐ |
IDD group vs. normal group (in bold).
**
P < 0.01.