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. 2019 Aug 28;25:43. doi: 10.1186/s10020-019-0107-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Construction of osteoporosis (OP) model induced by retinoic acid (RA). Mice were subjected to a femoral micro-CT assay of the whole femur (2D) and proximal femur, trabecular bone, and distal femur (3D) 15 d after RA administration (a). Bone volume over tissue volume (BV/TV) (b), number of trabeculae (Tb.N) (c), bone trabecular thickness (Tb.Th) (d), and trabecular separation (Tb.Sp) (e) were determined 15 d after RA administration. Control: normal mice, Model: RA-induced OP model mice. *, P < 0.05 vs control; n = 6 per group