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. 2019 Aug 28;25:43. doi: 10.1186/s10020-019-0107-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Osteoporosis (OP) was induced in mice with retinoic acid (RA). HE staining (40X) (a), femur bone mineral density determination (b), and TRACP staining (100X) (c) were performed to investigate the changes in femoral trabecular structure, bone density, and number of osteoclasts (d) in the OP model. Control: normal mice, Model: RA-induced OP model mice. *, P < 0.05 vs control; n = 6 per group