Table 2.

Nucleotide and amino acid substitution in EBNA-1 C-terminal domain compared to B95-8B sequence.

B95-8	109408	109409	109410	109423	109424	109425	109444	109445	109446	109447	109448	109449	109453	109454	109455	109507	109508	109509	109519	109520	109521
	487			492			499			500			502			520			524
	G	C	T	A	G	T	G	A	C	G	A	A	A	C	T	C	T	A	A	C	T
	Ala			Ser			Asp			Glu			Thr			Leu			Thr
T5	⋅	T	⋅	⋅	⋅	⋅	⋅	⋅	G	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	C	⋅	T	⋅
	Val			*			Glu			*			Asn			+			Ile
T6	⋅	T	⋅	⋅	⋅	⋅	⋅	⋅	G	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	C	⋅	T	⋅
	Val			*			Glu			*			Asn			+			Ile
T77	⋅	T	⋅	⋅	⋅	⋅	⋅	⋅	G	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	c	⋅	T	⋅
	Val			*			Glu			*			Asn			+			Ile
T70	⋅	T	⋅	⋅	⋅	⋅	⋅	⋅	G	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	c	⋅	T	⋅
	Val			*			Glu			*			Asn			+			Ile
T75	⋅	T	⋅	T	⋅	⋅	⋅	⋅	G	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	c	⋅	T	⋅
	Val			Cys			Glu			*			Asn			+			Ile

B95-8	109531	109532	109533	109534	109535	109536	109546	109547	109548	109606	109607	109608	109702	109703	109704	109711	109712	109713	109729	109730	109731
	528			529			533			553			585			588			594
	A	T	T	C	C	A	C	T	T	C	C	G	A	C	A	G	C	T	A	G	G
	Ile			Pro			Leu			Pro			Thr			Ala			Arg
T5	G	⋅	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	⋅	⋅	⋅	⋅	A	⋅
	Val			*			Ile			+			*			*			Lys
T6	G	⋅	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	⋅	A	⋅	T	⋅	⋅	⋅	⋅	⋅	A	⋅
	Val			*			Ile			+			Ile			*			Lys
T77	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	⋅	⋅	⋅	A	⋅	T	⋅	C	⋅	⋅	⋅	A	⋅
	*			Gin			*			+			Ile			Pro			Lys
T70	G	⋅	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	⋅	A	⋅	T	⋅	C	⋅	⋅	⋅	A	⋅
	Val			*			Ile			+			Ile			Pro			Lys
T75	G	⋅	⋅	⋅	⋅	⋅	A	⋅	⋅	⋅	⋅	A	⋅	T	⋅	C	⋅	⋅	⋅	A	⋅
	Val			*			Ile			+			Ile			Pro			Lys

NB: The top four rows correspond to the nucleotide, amino acid position, nucleotide and amino acid of B95-8 prototype sequence. In each row, the upper character denoted the nucleotide that is different to the B95-8 prototype sequence. Conversely, the dot (•) denotes the same nucleotide compared to the referent sequence. The characters below indicate the amino acid written in the three letter code that is different to the reference sequence, while the asterisk (*) indicates the unchanged amino acid, and the plus sign (+) indicates the silent amino acid changes.