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. 2019 Aug 22;9:796. doi: 10.3389/fonc.2019.00796

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Copyright © 2019 Fontanil, Mohamedi, Cobo, Cal and Obaya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antitumor effect of the fibulin-1/ADAMTS-1 interaction. Left, the fibulin-1/ADAMTS-1 interaction and its effects on tumor development. Right: ADAMTS-1 shows versicanase activity, which is potentiated by the presence of fibulin-1. Versikine, a byproduct of versican degradation, also shows antitumor properties. Bottom, protein motifs of ADAMTS, fibulin, and versican.