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. 2019 Aug 22;9:796. doi: 10.3389/fonc.2019.00796

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Copyright © 2019 Fontanil, Mohamedi, Cobo, Cal and Obaya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antitumor effect of the fibulin-2/ADAMTS-12 interaction. (A) The fibulin-2/ADAMTS-12 interaction enhances the antitumor effect of both proteins in breast cancer by reduction of the invasive and migration capacities and the mammosphere formation capacity of breast cancer cells. In addition, this interaction protects fibulin-2 against degradation by aggrecanases (mainly ADAMTS-5). (B) Aggrecanases (ADAMTS-4 and ADAMTS-5) are able to proteolitically process fibulin-2 and thus, abolish fibulin-2 antitumoral function. The fibulin-2 proteolysis results in an increase of the invasive and migration capacities and mammosphere formation capacity of breast cancer cells. Bottom, protein motifs of ADAMTSs and fibulin-2.