Table 2.

Association summary statistics of three significant CNV segments at 2q14.3 associated with CDAI-based response to TNF-α blocker therapy in 357 patients with RA

			Non-responder; n (%)			Responder; n (%)
Chr	Region	Regression coefficient of deletion (95% CI)	CN = 1	CN = 2	CN = 3	CN = 1	CN = 2	CN = 3	P
2	129,459,141–129,461,606	8.16 (4.52 to 11.79)	7 (22.9%)	25 (78.1%)	0 (0.0%)	13 (4.0%)	311 (95.7%)	1 (0.3%)	1.37 × 10−5
2	129,458,197–129,459,141	7.19 (3.68 to 10.70)	7 (22.9%)	25 (78.1%)	0 (0.0%)	15 (4.2%)	309 (95.1%)	1 (0.3%)	6.97 × 10−5
2	129,457,798–129,458,197	7.28 (3.69 to 10.86)	7 (22.9%)	25 (78.1%)	0 (0.0%)	14 (3.8%)	310 (95.4%)	1 (0.3%)	7.90 × 10−5

The copy number of 0 or ≥ 4 were not observed in the study subjects

CDAI clinical disease activity index, Chr chromosome, CI confidence interval, CN copy number