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. 2019 Aug 28;7:231. doi: 10.1186/s40425-019-0676-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — POG inhibits the proliferation and metabolism of PMN-MDSCs in vitro. a The cytotoxic effect of POG on PMN-MDSCs, CD8 T-lymphocytes and B16-F10 cells. b Effect of POG on the proliferation of PMN-MDSCs, CD8 T-lymphocytes and B16-F10 cells. c Statistical analysis of downregulated biological processes of B16-F10 tumour-bearing PMN-MDSCs after POG treatment. d Statistical analysis of the downregulated molecular function of B16-F10 tumour-bearing PMN-MDSCs after POG treatment. e KEGG analysis of the downregulated genes of B16-F10 tumour-bearing PMN-MDSCs after POG treatment. f GSEA analysis of the downregulated genes of B16-F10 tumour-bearing PMN-MDSCs after POG treatment. g The protein–protein interaction networks of downregulated proteins of B16-F10 tumour-bearing PMN-MDSCs after POG treatment. The pooled data from three independent experiments are shown. All data are represented as the mean ± SD. * p < 0.05, ** p < 0.01, ***p < 0.001, ****p < 0.0001