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. 2019 Aug 28;17:109. doi: 10.1186/s12964-019-0419-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Expression of canonical breast cancer subtype-markers in breast cancer cells and clinical samples. a Expression of canonical breast cancer subtype-markers in two normal breast cell lines, eight luminal, and seven BLBC cell lines by western blot (S: Short exposure; L: Long exposure). b Expression levels of selected canonical breast cancer subtype-marker mRNAs with Her-2 positive, luminal or basal-like specific based on bc-GenExMiner v4.1 according to the Sørlie’s subtypes (*p < 0.05; ****p < 0.0001; Red star: the former > the latter; Green Star: the former < the latter). Expression of selected luminal breast cancer markers (c) and basal-like specific marker Caveolin-1 (d) in representative Her-2 positive, luminal A, luminal B and basal-like breast cancer tissues by IHC (Red scale bar = 200 μm; Purple scale bar = 40 μm). e The association of selected luminal or basal-like specific markers expression between basal-like and non-BLBC tissue subtypes were assessed using Pearson’s χ2 test (for CK18, p = 0.0076; for FoxA1, p < 0.0001; for AGR2, p = 0.0002; for Caveolin-1, p < 0.0001; Red star, basal-like > non-basal-like; Green star, basal-like < non-basal-like)