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. 2019 Aug 28;17:109. doi: 10.1186/s12964-019-0419-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Canonical WNT signaling targets are preferentially overexpressed in BLBC. a List of Wnt ligand genes with AMP/DEL in 6370 invasive breast cancer patients based on TCGA data (AMP: Amplification; DEL: deletion). b List of Wnt/β-Catenin target genes with AMP in 6370 invasive breast cancer patients based on TCGA data (AMP: Amplification). c Overall survival analysis between Myc normal group and Myc amplified group (left); between CCND1 normal group and CCND1 amplified group (middle); and between Myc & CCND1 normal group and Myc &/or CCND1 amplified group (right). d Expression of canonical WNT signaling targets in two normal breast cell lines, eight luminal, and seven BLBC cell lines by western blot (S: Short exposure; L: Long exposure). e Expression levels of selected canonical WNT signaling target mRNAs with luminal or basal-like specific based on bc-GenExMiner v4.1 according to the Sørlie’s subtypes (****p < 0.0001; Red star: the former > the latter; Green Star: the former < the latter). f Expression of canonical WNT signaling targets in representative Her-2 positive, luminal A, luminal B and BLBC tissues by IHC (Red scale bar = 200 μm; Purple scale bar = 40 μm). g The association of canonical WNT signaling targets expression between basal-like and non-BLBC tissue subtypes were assessed using Pearson’s χ² test (for MET, p = 0.0287; for CD44, p = 0.0065; for TCF1/7, p = 0.0249; for c-Jun, p = 0.6547; for Cyclin D1, p = 0.0013; Red star, basal-like > non-basal-like; Green star, basal-like < non-basal-like; n.s.: no significant)