Table 2.
Measurements from infants who were randomized to resuscitation with an intact cord (intervention) or after early cord clamping (control). Intention to treat analysis
| Cord Clamping Group, Mean (SD) | Difference (95% CI) | P valuea | ||
|---|---|---|---|---|
| Intact cord > 3 min | Early < 1 min) | |||
| Readings from pulse oximeter | (n = 129) | (n = 93) | ||
| Saturation at 1 min (%) | 71.5 (9.3) | 62.4 (4.3) | 9.1 (7.3 to 11.0) | <.001 |
| Saturation at 5 min (%) | 83.6 (8.3) | 76.6 (4.1) | 7.0 (5.3 to 8.7) | <.001 |
| Saturation at 10 min (%) | 90.4 (8.1) | 85.4 (2.7) | 5.0 (3.5 to 6.5) | <.001 |
| Heart rate at 1 min | 105 (3) | 116 (5) | −10 (− 11 to −9) | <.001 |
| Heart rate at 5 min | 124 (4) | 134 (4) | −10 (− 11 to − 8) | <.001 |
| Heart rate at 10 min | 136 (2) | 135 (2) | 1 (0 to 1) | .03 |
| Apgar score | (n = 134) | (n = 97) | ||
| Apgar at 1 min | 5.1 (1.0) | 4.3 (1.0) | 0.8 (0.5 to 1.1) | <.001 |
| Apgar at 5 min | 6.8 (0.7) | 6.5 (1.1) | 0.3 (0.1 to 0.5) | .01 |
| Apgar at 10 min | 9.4 (1.0) | 9.0 (1.5) | 0.4 (0.2 to 0.7) | .03 |
| Timed events, Median (interquartile range) | (n = 134) | (n = 97) | ||
| Time of start of resuscitation (sec) | 45 (28 to 68) | 45 (25 to 59) | . 19b | |
| Time of first cry/breath (sec) | 37 (34 to 44) | 45 (38 to 50) | <.001b | |
| Time of regular breathing (sec)c | 78 (67 to 96) | 98 (89 to 356) | <.001b | |
| Time to cord clamping (sec) | 104 (30 to 191) | 25 (14 to 40) | <.001b | |
| Measurements after resuscitation | ||||
| Baby’s temperature (C°)d | 36.2 (0.5) | 36.2 (0.5) | 0.0 (−0.1 to 0.1) | .82 |
| Transcutaneous bilirubin (μmol/L) at dischargee | 97.8 (52.5) | 89.1 (52.6) | 8.6 (−5.5 to 23.0) | .23 |
aCalculated using an unpaired 2-tailed t test
bCalculated using Mann Whitney U test
cIntact cord group n = 132 and the early group n = 93
dIntact cord group n = 127 and the early group n = 90
eAge (hours) at discharge was median (interquartile range) 21.6 (15.4 to 31.6) in the intact cord group (n = 128) vs 22.2 (14.5 to 33.9) in the early group (n = 95), p = .83