Table 3.
Measurements from infants who were randomized to resuscitation with an intact cord (intervention) or after early cord clamping (control). Only infants handled according to allocation (per protocol) analyzed
| Cord Clamping Group, Mean (SD) | Difference (95% CI) | P valuea | ||
|---|---|---|---|---|
| Intact cord > 3 min | Early < 1 min | |||
| Readings from pulse oximeter | (n = 63) | (n = 93) | ||
| Saturation at 1 min (%) | 79.8 (3.6) | 62.4 (4.3) | 17.4 (16.1 to 18.7) | <.001 |
| Saturation at 5 min (%) | 91.4 (3.1) | 76.6 (4.1) | 14.8 (13.6 to 16.0) | <.001 |
| Saturation at 10 min (%) | 98.0 (1.4) | 85.4 (2.7) | 12.6 (11.8 to 13.3) | <.001 |
| Heart rate at 1 min | 105 (3) | 116 (5) | −11 (−12 to −10) | <.001 |
| Heart rate at 5 min | 125 (3) | 134 (4) | −9 (−10 to −7) | <.001 |
| Heart rate at 10 min | 137 (2) | 135 (2) | 2 (1 to 2) | <.001 |
| Apgar score | (n = 63) | (n = 93) | ||
| Apgar at 1 min | 5.7 (0.9) | 4.3 (0.9) | 1.4 (1.1 to 1.6) | <.001 |
| Apgar at 5 min | 7.0 (0.5) | 6.6 (0.9) | 0.5 (0.2 to 0.7) | <.001 |
| Apgar at 10 min | 9.6 (0.7) | 9.0 (1.3) | 0.6 (0.2 to 1.0) | .001 |
| Timed events, Median (interquartile range) | (n = 65) | (n = 97) | ||
| Time of start of resuscitation (sec) | 40 (22 to 60) | 45 (25 to 59) | .62b | |
| Time of first cry/breath (sec) | 34 (28 to 39) | 45 (38 to 50) | <.001b | |
| Time of regular breathing (sec)c | 69 (34 to 399) | 98 (89 to 356) | <.001b | |
| Time to cord clamping (sec) | 192 (188 to 200) | 25 (14 to 40) | <.001b | |
| Measurements after resuscitation | ||||
| Baby’s temperature (C°) 30 min after birthd | 36.2 (0.6) | 36.2 (0.5) | 0.0 (−0.2 to 0.2) | .82 |
| Transcutaneous bilirubin (μmol/L) at dischargee | 94.4 (44.1) | 89.1 (52.6) | 5.3 (−11.0 to 21.7) | .52 |
aCalculated using an unpaired 2-tailed t test
bCalculated using Mann Whitney U test
cIntact cord group n = 65 and the early group n = 93
dIntact cord group n = 64 and the early group n = 90
eAge (hours) at discharge was median (interquartile range) 22.5 (16.2 to 32.1) in the intact cord group (n = 61) vs 22.2 (14.5 to 33.9) in the early group (n = 95), p = .81