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. 2019 Aug 28;18:295. doi: 10.1186/s12936-019-2934-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Parasite line competitive growth assays suggest a fitness advantage in the NHP4026 line. NHP4026, a slow clearance kelch13-wt isolate, was able to fully outcompete all seven isolates it was matched with in pairwise competitions, suggesting a potential fitness advantage. In NHP4026 versus NF54 (kelch13-wt, fast clearance), NF54 initially held a greater ratio of parasitaemia, but NHP4026 overcame NF54 around day 30 and fully outcompeted NF54 by day 60 (n = 3; a). NHP4026 outcompeted NHP4076 (kelch13 E252Q, slow clearance) by day 24 (n = 3; b), and outcompeted NHP4333 (kelch13 G538V, slow-clearance) by day 40 (n = 3; c)