. 2019 Jun 20;8(4):235–240. doi: 10.4103/eus.eus_16_19

Table 1.

PEACE trial objectives

Primary objective	Secondary objectives
To determine the correlation between CEH-EUS parameters before and after treatment and tumor response. Tumor response will be assessed by contrast-enhanced computed tomography, according to the RECIST	To register CEH-EUS parameters before and after chemotherapy and to describe tumor changes in vascularity after treatment To determine the correlation between CEH-EUS parameters before treatment and overall survival and progression-free survival To determine the correlation between changes in tumor vascularity and PFS and OS To assess quantitative elastography parameters during EUS, before, and after systemic treatment and determine their correlation with overall survival and progression-free survival To examine the correlation between tumor vascularity and angiotensin inhibitors use To compare genomic changes based on whole-exome sequencing and transcriptome sequencing from pre- and post-treatment FNA samples

Primary objective

Secondary objectives

To determine the correlation between CEH-EUS parameters before and after treatment and tumor response.
Tumor response will be assessed by contrast-enhanced computed tomography, according to the RECIST

To register CEH-EUS parameters before and after chemotherapy and to describe tumor changes in vascularity after treatment
To determine the correlation between CEH-EUS parameters before treatment and overall survival and progression-free survival
To determine the correlation between changes in tumor vascularity and PFS and OS
To assess quantitative elastography parameters during EUS, before, and after systemic treatment and determine their correlation with overall survival and progression-free survival
To examine the correlation between tumor vascularity and angiotensin inhibitors use
To compare genomic changes based on whole-exome sequencing and transcriptome sequencing from pre- and post-treatment FNA samples

TIC: Time-intensity curve, CEH-EUS: Contrast-enhanced harmonic EUS, PFS: Progression-free survival, OS: Overall survival, RECIST: Response evaluation criteria in solid tumors, FNA: Fine needle aspiration