Appendix A.
Different needles performance on pancreatic lesions
| Performance | 20 PC (n=236) | 19 PC (n=11) | 22 PC (n=111) | 25 PC (n=70) |
|---|---|---|---|---|
| Age, years (mean±SD) | 68.3±11.8 | 64.9±8.4 | 64.7±12.6 | 70.2±9.8 |
| Number of passes (mean±SD) | 2.8±1.0 | 1.6±0.8 | 2.8±1.3 | 2.9±0.8 |
| Lesion site, n (%) | ||||
| Pancreatic head and uncinated process | 150 (63.6) | 4 (36.3) | 73 (65.7) | 58 (82.8) |
| Pancreatic body | 64 (27.1) | 7 (63.7) | 34 (30.6) | 11 (15.8) |
| Pancreatic tail | 22 (9.3) | 0 | 4 (3.7) | 1 (1.4) |
| Diagnostic adequacy, n (%) | 218 (92.4) | 10 (90.1) | 98 (88.3) | 61 (87.1) |
| Diagnostic performance for malignant lesions, % (95% CI) | ||||
| Overall accuracy | 91.5 (87.2-94.7) | 90.9 (58.7-99.8) | 88.3 (80.8-93.6) | 90 (80.5-95.9) |
| Sensitivity | 90.8 (86.1-94.3) | 90.9 (58.7-99.8) | 87.5 (79.6-93.2) | 88.5 (77.8-95.3) |
| Specificity | 100 (82.4-100) | - | 100 (59-100) | 100 (66.4-100) |
| Positive predictive value | 100 (98.1-100) | 100 (69.2-100) | 100 (96-100) | 100 (93.4-100) |
| Negative predictive value | 48.7 (32.4-65.2) | 0 (0-97.5) | 35 (15.4-59.2) | 56.2 (29.9-80.2) |
| Number needed to diagnose (NND) | 1.1 (1.1-1.5) | - | 1.1 (1.1-2.6) | 1.1 (1.1-2.3) |
| Number needed to misdiagnose (NNM) | 11.8 (7.8-18.9) | 11 (2.4-500) | 8.5 (5.2-15.6) | 10 (5.1-24.4) |