Table 3.

Comparison of the performance of different methods for predicting lung cancer on cross-validation.

Prediction method	Sample size	Sensitivity, %	Specificity, %	Area under the curve
RBLCa	226	96.30	94.97	0.99
Protein biomarker [31]	143	93.00	45.00	N/Ab
RNA biomarker [32]	310	93.00	90.00	0.97
DNA biomarker [30]	318	79.20	67.30	0.75
Computed tomography scans [43]	N/A	94.40	72.60	N/A

^aRBLC: routine blood indices model for lung cancer.

^bN/A: not applicable.