The AMP-based research design involves the true-experiment (A) and the sham-experiment (B). The figure illustrates the serial AMP-8 research design (Walleczek, in preparation). The concepts of (1) standard experiment (X/O), (2) systematic negative control (SNC; O/O), (3) systematic positive control (SPC; X/X), and (4) systematic time-reversed control (STC; O/X), in the true-experiment (A) as well as the accompanying sham-experiment (B) are shown. For an explanation of the use of the SNC (O/O), SPC (X/X), and STC (O/X) test trials, see Section “Three Additional Control Test Categories.” Illustrated in (A) is one possible sequence of six successive test trials, where X and O stand for intervention and control conditions, respectively. The serial progression in time is from left to right, whereby the sham-experiment is done either before or after the true-experiment in the serial AMP-format. The sham-experiment is illustrated in (B) and the sham-intervention and control conditions are labeled XS and OS, respectively. In the present work, the sham-experiment is done in the absence of any test subjects, as is indicated by the labels XS and OS in (B) in place of the labels X and O in (A). A total of 10,000 experimental trials (N = 1,250 test trials for each of the eight pre-specified test categories in the AMP-8 format) are performed as part of the commissioned replication study.