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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Neurobiol Dis. 2019 Jun 22;130:104502. doi: 10.1016/j.nbd.2019.104502

Figure 2. TFAM is reduced in neuronal processes and increased in astroglia in HAND frontal cortices compared to tissue from cognitively normal individuals.

Figure 2

(A and B) Immunostaining of TFAM in the frontal cortices of HAND (n=6) and CN (n=6) brain tissue and its quantification. (C) Double-immunostaining of TFAM and MAP2 in frontal cortices of HAND (n=4) and CN (n=4) brain tissue. (D-F) Quantification of TFAM signal, MAP2 signal, and % colocalization of TFAM/MAP2 signal. (G) Double-immunostaining of GFAP and TFAM in the frontal cortices of HAND and CN brain tissue. (H and I) Quantification of GFAP and % TFAM/GFAP colocalization. Statistical significance was determined by an unpaired t test. *, p<0.05, **, p<0.01.