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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Neurobiol Dis. 2019 Jun 22;130:104502. doi: 10.1016/j.nbd.2019.104502

Figure 3. mtDNA is decreased and IL-1β is increased in HAND brains exposed to ART.

Figure 3

DNA was isolated from HAND donors’ brains and mtDNA and IL1β was measured. (A and B) Quantification of mtDNA copies/cell stratified by HAND diagnosis and CN vs. HAND. (C and D) RNA was isolated from HAND donors’ brains and reverse transcribed to cDNA. Fold change of IL-1β was measured using RT2PCR with ACTB as a normalization control. The fold change in IL-1β expression stratified by HAND diagnosis and CN v. HAND was quantified. Statistical significance was determined by an unpaired t test. *, p<0.05.