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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Neurobiol Dis. 2019 Jun 22;130:104502. doi: 10.1016/j.nbd.2019.104502

Figure 9. Conditioned media from IL-1β-treated astroglia reduces neuronal TFAM and MAP2 expression, and this is reversed by WIN.

Figure 9

(A) Astroglia were treated with vehicle, WIN, IL-1β, and WIN+IL-1β for one day. Astroglial conditioned media was collected and used to treat primary neurons that were grown on glass coverslips, which were then fixed and immunostained for TFAM (red) and MAP2 (green). (B) Signal quantification of TFAM in primary neurons. (C) Signal quantification of MAP2 in primary neurons. All experiments were performed in three independent experiments using at least two astroglial lines and neuron lines with different genetic background. Data were analyzed by one-way ANOVA.