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Documented maturation stages of the CLR. (A) Clusters of mature CD83+ DCs with predominantly CD4+ T-cells; (B) Dense lymphocytic aggregates form without FDCs; (C) Primary follicle-like TLS, with an increasing abundance of B cells and FDCs, but no germinal center reaction; (D) Secondary follicle-like TLS, having active germinal centers. TLS, tertiary lymphoid structure; DC, dendritic cell; FDC, follicular dendritic cell.
